Publications

Scientific articles in Magazines & Webpages

As microscopic materials proliferate, ensuring they are safe is a priority
Horizon Magazine | Publication date: 14.11.2023 | Lead Beneficiary: HMGU; all partners contributing

Nanomaterialien: Unbedenklich oder Grund zur Sorge?
APA Science | Publication date: 21.11.2023 | Lead Beneficiary: HMGU; all partners contributing

Collaboration between BASF and TNO on Decision Support for Safe and Sustainable by Design - Interview to Wendel Wohlleben (BASF) and Wouter Fransmann (TNO)

Publications in Conference proceedings/Workshops

Conceptual Design of the HARMLESS Decision Support System
Poster @ NanoWeek 2022 (20-24 June 2022, Limassol, Cyprus) | TNO, TEMASOL, BASF | DOI: 10.5281/zenodo.6806190


Engineered nanomaterial-relevant AOPs; network creation and identification of key nodes for adverse outcomes
Presentation @ NanoWeek 2022 (20-24 June 2022, Limassol, Cyprus) | NRCWE, DTU, HMGU, INIA | DOI: 10.5281/zenodo.6806067


AOP training session
Lesson @ NanoWeek2022 (20-24 June 2022, Limassol, Cyprus) | NRCWE | DOI: 10.5281/zenodo.6806125


HARMLESS Workshop on SSbD for SMEs: AdMa in Product Development
Online (25 May 2023) | HMGU, CIT, TEMASOL, TNO, IDEA, BNN | DOI: 10.5281/zenodo.7974563


HARMLESS Decision Support System

Presentation at nanoSAFE 2023  (5-9 June 2023, Grenoble, France) | TNO | DOI: 10.5281/zenodo.8099067


Automatic workflow for HTS data FAIRification, preprocessing and Tox5 in-vitro toxicity scoring

Poster @ QSAR 2023 (5-9 June 2023, Copenhagen, Denmark) | IDEA, KI, Misvik | DOI: 10.5281/zenodo.8029959


Bayesian Network Models to combine and update models using incomplete data

Presentation @ Bayes Pharma 2023 (25-27 Oct. 2023 in Utrecht, Netherlands) | TNO | DOI: 10.5281/zenodo.10420899


Automatic workflow for in vitro high-throughput screening data FAIRification, preprocessing and scoring (Version 2)

Poster @ ECR Pitch Session on HARMLESS General Assembly (10-11 Jan. 2024, Ludwigshafen, Germany) | IDEA, KI, Misvik | DOI: 10.5281/zenodo.10517627


HARMLESS webinar on SSbD: demo with AdMa case studyAdMa in Product Development
Online (25 April 2024) | HMGU, TEMASOL, BASF, TNO, BNN | DOI: 10.5281/zenodo.11459527


P19-68 Identification of physico-chemical properties of 79 nanomaterials that are predictive of inflammation and genotoxicity following pulmonary exposure in mice

Poster at EUROTOX 2024 (8-11 Sept. 2024, Copenhagen) - Toxicology Letters (special issue: Abstracts of the 58th Congress of the European Societies of Toxicology (EUROTOX 2024): TOXICOLOGY - A QUEST FOR SAFER CHEMICALS AND MEDICINES) | NRCWE | DOI: 10.1016/j.toxlet.2024.07.677


NMBP-16 Ambassadors - Cooperation as cornerstone of our success

Poster at NanoTox 2024 (23-25 Sept. 2024, Venice, Italy) | BNN, HMGU | DOI: 10.5281/zenodo.13908183


Automatic workflow for in vitro high-throughput screening data FAIRification, preprocessing and scoring: A case study on nanomaterials (Version 3)

Poster @ NanoTox 2024 (23-25 Sept. 2024, Venice, Italy) | IDEA, KI, Misvik | DOI: 10.5281/zenodo.13986392


HARMLESS SSbD Approach and Decision Support System for Advanced Nanomaterials

Presentation @ SSbD24 conference (10-15 Nov. 2024, Monte Verità, Switzerland) | TNO, TEMASOL, BASF | DOI: 10.5281/zenodo.14279205

Scientific Publications
2025
2024

Cell circuits underlying nanomaterial specific respiratory toxicology - Scientific preprint

bioRxiv (2024) | HMGU, NRCWE | DOI: 10.1101/2024.02.10.579746


Similarity of multicomponent nanomaterials in a safer-by-design context: the case of core–shell quantum dots
Environmental science: Nano, on the special issue on Advanced Materials (2024) | BASF, DTU, IDEA, UG, HMGU | DOI: 10.1039/D3EN00338H


Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery
Advanced Science (2024), 2308659 | HMGU | DOI: 10.1002/advs.202308659


Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure
Environ.Toxicol. and Pharmacol.(2024), Vol.107, 104413 | NRCWE | DOI: 10.1016/j.etap.2024.104413


A screening approach to the Safe-and-Sustainable-by-Design development of Advanced insulation Materials

Small 2024, Vol.20, Issue 32, 2311155 | BASF, NRCWE, TNO | DOI: 10.1002/smll.202311155


Acute, controlled inhalation of thin graphene oxide nanosheets in humans with null cardiorespiratory effects

Nature Nanotechnology (2024), Vol.19, Issue 5, 582-583 | NRCWE | DOI: 10.1038/s41565-024-01639-9


Roadmap Safe and Sustainable Advanced and Innovative Materials 2024-2030 (Version v5) - Preprint
Zenodo (2024) | BNN, KI, TEMASOL | DOI: 10.5281/zenodo.11191095


Everything falls apart: How solids degrade and release nanomaterials, composite fragments, and microplastics
NanoImpact (2024), Vol. 34, 100510 | BASF, TEMASOL | DOI: 10.1016/j.impact.2024.100510


Advanced Materials Earliest Assessment (AMEA)
Environ. Sci.: Nano (2024), Advance Article | BASF, CIT, TEMASOL, DTU, TNO, BauA, HMGU, BfR | DOI: 10.1039/D3EN00831B


Advancing Nanomaterial Toxicology Screening through Efficient and Cost-Effective Quantitative Proteomics
Small Methods (2024), 2400420 | BfR | DOI: 10.1002/smtd.202400420


Roadmap safe and sustainable advanced and innovative materials. (Outlook for 2024-2030)
CSBJ: Nano (2024), Vol.25, 105-106 | BNN, KI, TEMASOL | DOI: 10.1016/j.csbj.2024.05.018


Bioinformatics and machine learning to support nanomaterial grouping
Nanotoxicology (2024), Vol. 18, Issue 4, 1-28 | BfR, BASF, KI, NRCWE | DOI: 10.1080/17435390.2024.2368005


Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives
NanoImpact (2024), Vol.35, 100523 | TNO, SU, UG, KI, HMGU, TEMASOL, NRCWE, BASF | DOI: 10.1016/j.impact.2024.100523


In-vitro High-throughput screening data

Zenodo | IDEA, Misvik, KI | DOI: 10.5281/zenodo.13683162


Orange3-ToxFAIRy visual guide (Widget usage examples)

Zenodo | IDEA, Misvik, KI | DOI: 10.5281/zenodo.13685297


Oxide-perovskites for automotive catalysts bio-transform and induce multi-component clearance and hazard
ACS Nano (2024), Vol.18, Issue 47 | BASF, DTU, NRCWE, UG | DOI: 10.1021/acsnano.4c10135


The oxidative potential of nanomaterials: an optimized high-throughput protocol and interlaboratory comparison for the ferric reducing ability of serum (FRAS) assay
Nanotoxicology (2024), Vol.18, Issue 8 | TNO, BASF | DOI: 10.5281/zenodo.14526122


2023

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials
RSC Sustain. (2023), 1, 234-250 | BNN | DOI: 10.1039/d2su00101b


From Principles to Reality. FAIR Implementation in the Nanosafety Community
Zenodo (2023). | BfR, Misvik, IDEA, KI, TEMASOL | DOI: 10.5281/zenodo.7614989


Breathing-induced stretch enhances the efficacy of an inhaled and orally delivered anti-fibrosis drug in vitro
Journal of Drug Delivery Science and Technology (2023), 82, 104316 | HMGU | DOI: 10.1016/j.jddst.2023.104316


Editorial: Exploring impacts of combined exposures to particles and chemicals on immune reactions across living organisms
Front. Toxicol., (2023), Sec. Immunotoxicology, 5 | HMGU | DOI: 10.3389/ftox.2023.1148374


Single-walled vs. Multi-walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses of Mouse Lungs
Nanomaterials (2023), 13(6), 1059 | NRCWE, Environmental Health Science and Research Bureau Canada (HARMLESS Advisory Board) | DOI: 10.3390/nano13061059


ERS International Congress 2022: highlights from the Basic and Translational Science Assembly
Erj Open Research (2023) | HMGU | DOI: 10.1183/23120541.00561-2022


Transferability and reproducibility of exposed air-liquid interface co-culture lung modelsFrom Principles to Reality. FAIR Implementation in the Nanosafety
NanoImpact (2023), 31, 100466 | HMGU, BASF, SU | DOI: 10.1016/j.impact.2023.100466


Effect of Exposure Concentration and Growth Conditions on the Association of Cerium Oxide Nanoparticles with Green Algae
Nanomaterials 2023, 13 (17) | DTU | DOI: 10.3390/nano13172468


Advanced Materials Assessment Schemes HARMLESS - OECD Working Party on Manufactured Nanomaterials (WPMN) Workshop Report
OECD Environment, Health and Safety Publications Series on the Safety of Manufactured Nanomaterials No. 107. ENV/CBC/MONO(2023)34. | TEMASOL, TNO, DTU, HMGU, BASF SE, BfR

Nanoparticle-Exposure-Triggered Virus Reactivation Induces Lung Emphysema in Mice
ACS Nano 2023, 17, 21, 21056-21072 | HMGU | DOI: 10.1021/acsnano.3c04111

Behaviour of Advanced Materials in environmental aquatic media - Dissolution kinetic and dispersion stability of perovskite automotive catalyst
Royal society of Chemistry (2023) | BASF, DTU | DOI: 10.1039/D3EN00685A


Meta-Analysis of Integrated Proteomic and Transcriptomic Data Discerns Structure–Activity Relationship of Carbon Materials with Different Morphologies

Advanced Science (2023) | BfR, KI | DOI: 10.1002/advs.202306268

2022
2021

Towards Computer-Aided Graphene Covered TiO2-Cu/(CuxOy) Composite Design for the Purpose of Photoinduced Hydrogen Evolution
Catalysts 2021, 11(6) | UG | DOI: 10.3390/catal11060698


INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies) - Version 1.0
Zenodo (2021) | BNN | DOI: 10.5281/zenodo.5004929


ELIXIR and Toxicology: a community in development
F1000Research (2021), 10(ELIXIR):1129 | KI, Misvik, IDEA | DOI: 10.12688/f1000research.74502.1


A novel quantitative read-across tool designed purposefully to fill the existing gaps in nanosafety data
Environ. Sci.: Nano, 2022, 9, 189-203 | GU | DOI: 10.1039/d1en00725d


Reply to: Prospects and challenges for FAIR toxicogenomics data
Nature Nanotechnology (2022), 17, 19–20 | Misvik, KI, BfR, IDEA |  DOI: 10.1038/s41565-021-01050-8

Articles in external Newsletters

EU NSC Newsletter #22 (March 2021): General HARMLESS project presentation

EU NSC Newsletter #24 (Oct. 2021): Presentation of HARMLESS project flyer

EU NSC Newsletter #26: Presentation of HARMLESS case studies to the OECD

EU NSC Newsletter #27: Promotion of HARMLESS activities

NSC Update #01/2023 (June 2023): Promotion of the participation of the NMBP-16 sister projects at NanoSafety Training School 2023, nanoSAFE 2023, report about HARMLESS workshop on "SSbD for SMEs",  group on the NSC website

NSC Update #02/2024: Promotion of the NMBP-16 sister project group on the NSC website

NSC Update #10/2024: Promotion of HARMLESS activities (HARMLESS factsheet on perovskites, recap of NanoTox 2024 and recap of NMBP-16 final event)

NSC Update #12/2024: Promotion in the NSC Update #12/2024 (lauch of the WASP tool and the HARMLESS factsheet on ToxFAIRy software)





BNN Newsletter 01/2021 (#50 - March 2021): General HARMLESS project presentation

BNN Newsletter 02/2021 (July 2021): 2 articles (HARMLESS @ 1st Stakeholder workshop on SSbD // HARMLESS @ Global Innovation Summit)

BNN Newsletter 03/2021 (Sept. 2021): Presentation of HARMLESS project flyer

BNN Newsletter 01/2022: Promotion of cooperation with OECD

BNN Newsletter 02/2022: 2 articles (promotion of project video, NanoSafety Traning School 2022)

BNN QUARTERLY 03/2022: 3 articles (participation at BioCeramics32, ERN 2022 and NanoWeek 2022)

BNN QUARTERLY 04/2022: 2 articles (promotion of HARMLESS activities: HARMLESS/OECD SG AdMa workshop  on 15 Nov. // collaborationof HARMLESS in the IRISS workshop in Nov.2022)

BNN QUARTERLY 01/2023: Promotion of HARMLESS activities: NMBP-16 Ambassadors meeting on 16 Jan.

BNN QUARTERLY 02/2023: 5 articles promoting HARMLESS activities: participation at NonoSafety Training School 2023, nanoSAFE 2023, NMBP-16 Ambassados meeting in Grenoble,  ENF 2023, HARMLESS workshop on SSbD for SMEs

BNN QUARTERLY 03/2023: Promotion of HARMLESS participation in ANTHOS'24

BNN QUARTERLY 04/2023: Promotion of HARMLESS co-organisation of in ANTHOS'24

BNN QUARTERLY 01/2024: Promotion of HARMLESS activities (knowledge exchange with ECHA, promotion of future events organised by HARMLESS (webinar with DSS demo, NanoTox 2024)

BNN QUARTERLY 02/2024: Article promoting the “HARMLESS Webinar on SSbD: DSS Demo with AdMa Case Study”

BNN QUARTERLY 03/2024: Article promoting HARMLESS' participation at MaterialsWeek 2024

BNN QUARTERLY 04/2024: Five articles reporting on HARMLESS' participation at NanoTox 2024, at EuropeanResearchers' Night 2024, organisation of the NMBP-16 projects Public Final Event, reflexions on the JRC Nanobiotechnology Training and Capacity Building Week 2024, as well as the promotion of the factsheet on the perovskites (Catalysts Case Study)

Project Deliverables

Deliverable 1.1 - HARMLESS database with extension to handle advanced materials
Submission date: 23.01.2023 | Lead Beneficiary: IDEA | DOI: 10.5281/zenodo.14097538


Deliverable 2.1 - Overview of relevant AOPs to inform NAM choice of KEs
Submission date: 31.01.2022 | Lead Beneficiary: NRCWE | DOI: 10.5281/zenodo.10556303


Deliverable 2.3 – Bioaccumulation and persistency evaluation of selected NMs

Submission date: 29.08.2023 | Lead Beneficiary: DTU | DOI: 10.5281/zenodo.14105537


Deliverable 2.4 - Open access repository of mRNA single cell response
Submission date: 13.05.2024 | Lead Beneficiary: HMGU | DOI: 10.5281/zenodo.13950977

C&D Material

HARMLESS Factsheet on Catalysts Case Study: Oxide-perovskites for automotive catalysts

Lead Beneficiary: BASF | Creator: BNN | DOI: 10.5281/zenodo.13861859


Factsheet on ToxFAIRy: The HARMLESS software solution for automated toxicity scoring and FAIRification of data

Lead Beneficiary: IDEA, MISVIK | Creator: BNN | DOI: 10.5281/zenodo.14526121

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HARMLESS

EU-funded H2020 Research & Innovation Action addressing Safe-by-Design of multicomponent nanomaterials running from January 2021 - January 2025

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