National Institute for Agricultural and Food Research and Technology (INIA)


José María Navas
Ecotoxicity assessment involving mechanistic high-throughput in vitro assays using fish cell lines


Mona Connolly
Ecotoxicity assessment, confirmatory in vivo studies in fish and higher tier fish bioaccumulation testing

Nanomaterial acute toxicity and bioaccumulation in fish

The Spanish National Institute for Agricultural and Food Research and Technology (INIA) is an autonomous Public Research Organization (OPI) belonging to the Ministry of Science and Innovation. INIA carries out R&D&i activities through its Deputy Directorate General for Research and Technology (SGIT). SGIT personnel in 2019 included 147 research scientists, 80 technologists, 160 technicians, and 268 hired personnel and grants. A total of 221 projects were carried out (from them 28 were funded by the EU and 5 by other international programs). At the INIA the activity of the Department of Environment focuses on ecotoxicology and risk assessment of chemicals and nanomaterials in a regulatory framework. In this Department, the research group for Endocrine Disruptors and Toxicity of Contaminants (EDTC), participating in the present application, concentrates its work on the study of the mechanisms underlying the toxic action of chemicals and manufactured nanomaterials. As a charge of the Ministry for Ecological Transition and Demographic Challenge (MITECO) INIA collaborates in the environmental risk assessment (ERA) and registration of pesticides, biocides and chemicals at the national and European levels. In particular, the scientists of the EDTC group are Spanish representatives, named by the Spanish Competent Authority, in a number of working groups at the OECD, EC and ECHA.

Main activities within HARMLESS:

  • Determination of nanomaterial acute toxicity and bioaccumulation in fish
  • Studies about the mechanisms underlying the ecotoxicological action of nanomaterials using in vitro approaches based on fish cell lines
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