Tobias Stöger & Otmar Schmid
Scientific Role: From exposure to tissue-delivered dose of inhaled nanomaterials, in vitro/ in vivo/ human translation of dose-response curves, hazard classification of NMs
The Helmholtz Zentrum München (HMGU), the German Research Center for Environmental Health, is a governmentally funded research institution with 2.550 employees (48 institutes and departments), which focuses on common diseases developing from the interaction of lifestyle, environmental factors and personal genetic background, and particularly on chronic lung diseases, diabetes mellitus and neurodegenerative diseases. For decades, the Institute of Lung Biology and Disease (iLBD), which belongs to the Comprehensive Pneumology Center (CPC, member of the German Center for Lung Research) (ca. 150 employees), has been engaged in the fields of Environmental Health and Translational Clinical Science in general and in the pursuit of the underlying molecular mechanisms of inhalation toxicology and related adverse health effects in particular.
Main activities in the project:
In vitro data integration of nanomaterials (WP1), in vivo model translation and strategic single-cell based lung toxicity studies (WP2), identification of candidate KEs and AOs for development of nanomaterials’ descriptors (WP2) and New Approach Methodologies (WP3), in vitro nanomaterial dosimetry and in vitro to in vivo extrapolation from cells to humans (WP3), Coordination and management (WP8).