In February, 18 international partners kicked off project HARMLESS. HARMLESS will build upon our safe-by-design strategies for Advanced Materials in combination with the available data complemented by newly generated HARMLESS data with the aim to develop computational tools for different scales and stages of AM development. HARMLESS will adopt a novel, multifaceted Safe Innovation Approach to NM&HARNs from applying and integrating a New Approach Methodologies toolbox and NAM-derived safety testing data into stage-gated comprehensive Integrated Approaches to Testing and Assessment (IATAs).